The pyruvate dehydrogenase complexes: structure-based function and regulation
The pyruvate dehydrogenase complexes (PDCs) from all known living organisms comprise
three principal catalytic components for their mission: E1 and E2 generate acetyl-coenzyme
A, whereas the FAD/NAD+-dependent E3 performs redox recycling. Here we compare
bacterial (Escherichia coli) and human PDCs, as they represent the two major classes of the
superfamily of 2-oxo acid dehydrogenase complexes with different assembly of, and
interactions among components. The human PDC is subject to inactivation at E1 by serine …
three principal catalytic components for their mission: E1 and E2 generate acetyl-coenzyme
A, whereas the FAD/NAD+-dependent E3 performs redox recycling. Here we compare
bacterial (Escherichia coli) and human PDCs, as they represent the two major classes of the
superfamily of 2-oxo acid dehydrogenase complexes with different assembly of, and
interactions among components. The human PDC is subject to inactivation at E1 by serine …
