Molecular regulation of MCU: Implications in physiology and disease
N Nemani, S Shanmughapriya, M Madesh - Cell Calcium, 2018 - Elsevier
Ca 2+ flux across the inner mitochondrial membrane (IMM) regulates cellular bioenergetics,
intra-cellular cytoplasmic Ca 2+ signals, and various cell death pathways. Ca 2+ entry into
the mitochondria occurs due to the highly negative membrane potential (ΔΨ m) through a
selective inward rectifying MCU channel. In addition to being regulated by various
mitochondrial matrix resident proteins such as MICUs, MCUb, MCUR1 and EMRE, the
channel is transcriptionally regulated by upstream Ca 2+ cascade, post transnational …
intra-cellular cytoplasmic Ca 2+ signals, and various cell death pathways. Ca 2+ entry into
the mitochondria occurs due to the highly negative membrane potential (ΔΨ m) through a
selective inward rectifying MCU channel. In addition to being regulated by various
mitochondrial matrix resident proteins such as MICUs, MCUb, MCUR1 and EMRE, the
channel is transcriptionally regulated by upstream Ca 2+ cascade, post transnational …