Arginase activity is associated with fibrosis in experimental infection with Taenia crassiceps, but does not play a major role in resistance to infection
VBL Moura, MM Silva, LF Batista, CM Gomes… - Experimental …, 2013 - Elsevier
Murine infection with Taenia crassiceps cysticerci is used as an experimental model for
human and animal cysticercosis. In this infection parasites can be found associated with an
inflammatory infiltrate enriched with macrophages. Experimental evidence exists supporting
a role for either NO-producing classically activated (CAMΦ) or arginase-and CD301-
expressing alternatively activated macrophages (AAMΦ) in T. crassiceps resistance. In both
cell types, arginine is utilized as an important mediator in macrophage effector functions. To …
human and animal cysticercosis. In this infection parasites can be found associated with an
inflammatory infiltrate enriched with macrophages. Experimental evidence exists supporting
a role for either NO-producing classically activated (CAMΦ) or arginase-and CD301-
expressing alternatively activated macrophages (AAMΦ) in T. crassiceps resistance. In both
cell types, arginine is utilized as an important mediator in macrophage effector functions. To …