Dopamine's actions in primate prefrontal cortex: challenges for treating cognitive disorders
AFT Arnsten, M Wang, CD Paspalas - Pharmacological reviews, 2015 - Elsevier
The prefrontal cortex (PFC) elaborates and differentiates in primates, and there is a
corresponding elaboration in cortical dopamine (DA). DA cells that fire to both aversive and
rewarding stimuli likely project to the dorsolateral PFC (dlPFC), signaling a salient event.
Since 1979, we have known that DA has an essential influence on dlPFC working memory
functions. DA has differing effects via D1 (D1R) versus D2 receptor (D2R) families. D1R are
concentrated on dendritic spines, and D1/5R stimulation produces an inverted U-shaped …
corresponding elaboration in cortical dopamine (DA). DA cells that fire to both aversive and
rewarding stimuli likely project to the dorsolateral PFC (dlPFC), signaling a salient event.
Since 1979, we have known that DA has an essential influence on dlPFC working memory
functions. DA has differing effects via D1 (D1R) versus D2 receptor (D2R) families. D1R are
concentrated on dendritic spines, and D1/5R stimulation produces an inverted U-shaped …