Microinjection of valproic acid into the ventrolateral orbital cortex exerts an antidepressant-like effect in the rat forced swim test
B Xing, Y Zhao, H Zhang, Y Dang, T Chen, J Huang… - Brain research …, 2011 - Elsevier
Valproic acid (VPA), widely used as mood stablizer, has been shown therapeutic effects in
controlling both episodes of mania and depression. The neurobiological actions by which
valproic acid exerts these effects have not been established. Ventrolateral orbital cortex
(VLO) is a subregion of orbitofrontal cortex (OFC) that has been closely associated with
depression. However, there are few studies aimed at investigating the role of the VLO in the
neurobiology of depression. In the present study, we investigated the effects on rat forced …
controlling both episodes of mania and depression. The neurobiological actions by which
valproic acid exerts these effects have not been established. Ventrolateral orbital cortex
(VLO) is a subregion of orbitofrontal cortex (OFC) that has been closely associated with
depression. However, there are few studies aimed at investigating the role of the VLO in the
neurobiology of depression. In the present study, we investigated the effects on rat forced …
