Neuroimaging studies of major depression have identified neurophysiologic abnormalities
in multiple areas of the orbital and medial prefrontal cortex, the amygdala, and related parts
of the striatum and thalamus. Some of these abnormalities appear mood state–dependent
and are located in regions where cerebral blood flow increases during normal and other
pathologic emotional states. These neurophysiologic differences between depressives and
control subjects may thus implicate areas where physiologic activity changes to mediate or …