Lesions of ventrolateral prefrontal or anterior orbitofrontal cortex in primates heighten negative emotion
C Agustín-Pavón, K Braesicke, Y Shiba… - Biological …, 2012 - Elsevier
BACKGROUND: Heightened fear and anxiety are core symptoms of a variety of
neuropsychiatric disorders. They are associated with structural and activity changes
throughout neural circuitry that includes the ventral and medial prefrontal cortices (PFC), the
amygdala, and hippocampus. Although the contributions of the medial PFC, amygdala, and
hippocampus to fear and anxiety have been studied extensively with animal models, the
selective roles of the ventral PFC—including the ventrolateral prefrontal cortex (vlPFC) and …
neuropsychiatric disorders. They are associated with structural and activity changes
throughout neural circuitry that includes the ventral and medial prefrontal cortices (PFC), the
amygdala, and hippocampus. Although the contributions of the medial PFC, amygdala, and
hippocampus to fear and anxiety have been studied extensively with animal models, the
selective roles of the ventral PFC—including the ventrolateral prefrontal cortex (vlPFC) and …