NZM2328: a new mouse model of systemic lupus erythematosus with unique genetic susceptibility loci
ST Waters, SM Fu, F Gaskin, US Deshmukh… - Clinical …, 2001 - Elsevier
Among NZB/W-derived New Zealand mixed (NZM) strains, only NZM/Aeg2410 (NZM2410)
has been well characterized. In contrast to NZM2410, NZM2328 mice develop
autoantibodies and acute and severe chronic glomerulonephritis (GN) with female
predominance similarly to NZB/WF1 and humans with systemic lupus erythematosus (SLE).
Chronic GN with glomerular sclerosis and tubular atrophy but not acute GN was correlated
with severe proteinuria. In a backcross analysis of (NZM2328 X C57L/J) F1 X NZM2328, four …
has been well characterized. In contrast to NZM2410, NZM2328 mice develop
autoantibodies and acute and severe chronic glomerulonephritis (GN) with female
predominance similarly to NZB/WF1 and humans with systemic lupus erythematosus (SLE).
Chronic GN with glomerular sclerosis and tubular atrophy but not acute GN was correlated
with severe proteinuria. In a backcross analysis of (NZM2328 X C57L/J) F1 X NZM2328, four …