Signal regulatory protein alpha is present in several neutrophil granule populations and is rapidly mobilized to the cell surface to negatively fine-tune neutrophil …
Ć Stenberg, A Karlsson, E Feuk-Lagerstedt… - Journal of Innate …, 2014 - karger.com
Ć Stenberg, A Karlsson, E Feuk-Lagerstedt, K Christenson, J Bylund, A Oldenborg…
Journal of Innate Immunity, 2014•karger.comSignal regulatory protein alpha (SIRPα) is a cell surface glycoprotein with inhibitory
functions, which may regulate neutrophil transmigration. SIRPα is mobilized to the neutrophil
surface from specific granules, gelatinase granules, and secretory vesicles following
inflammatory activation in vitro and in vivo. The lack of SIRPα signaling and the ability to
upregulate SIRPα to the cell surface promote neutrophil accumulation during inflammation
in vivo.
functions, which may regulate neutrophil transmigration. SIRPα is mobilized to the neutrophil
surface from specific granules, gelatinase granules, and secretory vesicles following
inflammatory activation in vitro and in vivo. The lack of SIRPα signaling and the ability to
upregulate SIRPα to the cell surface promote neutrophil accumulation during inflammation
in vivo.
Abstract
Signal regulatory protein alpha (SIRPα) is a cell surface glycoprotein with inhibitory functions, which may regulate neutrophil transmigration. SIRPα is mobilized to the neutrophil surface from specific granules, gelatinase granules, and secretory vesicles following inflammatory activation in vitro and in vivo. The lack of SIRPα signaling and the ability to upregulate SIRPα to the cell surface promote neutrophil accumulation during inflammation in vivo.
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