ACE inhibition restores the vasodilator potency of the endothelium-derived relaxing factor, LS-nitrosocysteine, in conscious Spontaneously Hypertensive rats
SJ Lewis, MP Hashmi-Hill, JR Owen, K Sandock… - Vascular …, 2006 - Elsevier
OBJECTIVE: The major aim of this study was to determine whether the angiotensin
converting enzyme (ACE) inhibitors, captopril or enalapril, restore the diminished vasodilator
potency of the endothelium-dependent agonist, acetylcholine (ACh), and the endothelium-
derived relaxing factor (EDRF), lS-nitrosocysteine (L-SNC), in conscious Spontaneously
Hypertensive (SH) rats. METHODS: The hemodynamic responses elicited by iv injections of
ACh, L-SNC, and nitric oxide donors such as MAHMA NONOate, were determined in SH rats …
converting enzyme (ACE) inhibitors, captopril or enalapril, restore the diminished vasodilator
potency of the endothelium-dependent agonist, acetylcholine (ACh), and the endothelium-
derived relaxing factor (EDRF), lS-nitrosocysteine (L-SNC), in conscious Spontaneously
Hypertensive (SH) rats. METHODS: The hemodynamic responses elicited by iv injections of
ACh, L-SNC, and nitric oxide donors such as MAHMA NONOate, were determined in SH rats …
