Ventilatory responses during and following exposure to a hypoxic challenge in conscious mice deficient or null in S-nitrosoglutathione reductase
LA Palmer, WJ May, K deRonde… - Respiratory physiology …, 2013 - Elsevier
Exposure to a hypoxic challenge increases ventilation in wild-type (WT) mice that diminish
during the challenge (roll-off) whereas return to room air causes an increase in ventilation
(short-term facilitation, STF). Since plasma and tissue levels of ventilatory excitant S-
nitrosothiols such as S-nitrosoglutathione (GSNO) increase during hypoxia, this study
examined whether (1) the initial increase in ventilation is due to generation of GSNO,(2) roll-
off is due to increased activity of the GSNO degrading enzyme, GSNO reductase (GSNOR) …
during the challenge (roll-off) whereas return to room air causes an increase in ventilation
(short-term facilitation, STF). Since plasma and tissue levels of ventilatory excitant S-
nitrosothiols such as S-nitrosoglutathione (GSNO) increase during hypoxia, this study
examined whether (1) the initial increase in ventilation is due to generation of GSNO,(2) roll-
off is due to increased activity of the GSNO degrading enzyme, GSNO reductase (GSNOR) …
