Tumor-infiltrating dendritic cells in cancer pathogenesis

JM Tran Janco, P Lamichhane… - The Journal of …, 2015 - journals.aai.org
JM Tran Janco, P Lamichhane, L Karyampudi, KL Knutson
The Journal of Immunology, 2015journals.aai.org
Dendritic cells (DCs) play a pivotal role in the tumor microenvironment, which is known to
affect disease progression in many human malignancies. Infiltration by mature, active DCs
into the tumors confers an increase in immune activation and recruitment of disease-fighting
immune effector cells and pathways. DCs are the preferential target of infiltrating T cells.
However, tumor cells have means of suppressing DC function or of altering the tumor
microenvironment in such a way that immune-suppressive DCs are recruited. Advances in …
Abstract
Dendritic cells (DCs) play a pivotal role in the tumor microenvironment, which is known to affect disease progression in many human malignancies. Infiltration by mature, active DCs into the tumors confers an increase in immune activation and recruitment of disease-fighting immune effector cells and pathways. DCs are the preferential target of infiltrating T cells. However, tumor cells have means of suppressing DC function or of altering the tumor microenvironment in such a way that immune-suppressive DCs are recruited. Advances in understanding these changes have led to promising developments in cancer-therapeutic strategies targeting tumor-infiltrating DCs to subdue their immunosuppressive functions and enhance their immune-stimulatory capacity.
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