[HTML][HTML] Cancer susceptibility gene mutations in individuals with colorectal cancer
MB Yurgelun, MH Kulke, CS Fuchs… - Journal of Clinical …, 2017 - ncbi.nlm.nih.gov
Journal of Clinical Oncology, 2017•ncbi.nlm.nih.gov
Purpose Hereditary factors play an important role in colorectal cancer (CRC) risk, yet the
prevalence of germline cancer susceptibility gene mutations in patients with CRC
unselected for high-risk features (eg, early age at diagnosis, personal/family history of
cancer or polyps, tumor microsatellite instability [MSI], mismatch repair [MMR] deficiency) is
unknown.
prevalence of germline cancer susceptibility gene mutations in patients with CRC
unselected for high-risk features (eg, early age at diagnosis, personal/family history of
cancer or polyps, tumor microsatellite instability [MSI], mismatch repair [MMR] deficiency) is
unknown.
Abstract
Purpose
Hereditary factors play an important role in colorectal cancer (CRC) risk, yet the prevalence of germline cancer susceptibility gene mutations in patients with CRC unselected for high-risk features (eg, early age at diagnosis, personal/family history of cancer or polyps, tumor microsatellite instability [MSI], mismatch repair [MMR] deficiency) is unknown.
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