Role of the calcium-sensing receptor in calcium regulation of epidermal differentiation and function
CL Tu, DD Bikle - Best practice & research Clinical endocrinology & …, 2013 - Elsevier
The epidermis is a stratified squamous epithelium composed of proliferating basal and
differentiated suprabasal keratinocytes. It serves as the body's major physical and chemical
barrier against infection and harsh environmental insults, as well as preventing excess water
loss from the body into the atmosphere. Calcium is a key regulator of the proliferation and
differentiation in keratinocytes. Elevated extracellular Ca 2+ concentration ([Ca 2+] o) raises
the levels of intracellular free calcium ([Ca 2+] i), promotes cell–cell adhesion, and activates …
differentiated suprabasal keratinocytes. It serves as the body's major physical and chemical
barrier against infection and harsh environmental insults, as well as preventing excess water
loss from the body into the atmosphere. Calcium is a key regulator of the proliferation and
differentiation in keratinocytes. Elevated extracellular Ca 2+ concentration ([Ca 2+] o) raises
the levels of intracellular free calcium ([Ca 2+] i), promotes cell–cell adhesion, and activates …
