[HTML][HTML] Kidney-induced cardiac allograft tolerance in miniature swine is dependent on MHC-matching of donor cardiac and renal parenchyma
ML Madariaga, SG Michel, GM La Muraglia II… - American Journal of …, 2015 - Elsevier
Kidney allografts possess the ability to enable a short course of immunosuppression to
induce tolerance of themselves and of cardiac allografts across a full-MHC barrier in
miniature swine. However, the renal element (s) responsible for kidney-induced cardiac
allograft tolerance (KICAT) are unknown. Here we investigated whether MHC disparities
between parenchyma versus hematopoietic-derived “passenger” cells of the heart and
kidney allografts affected KICAT. Heart and kidney allografts were co-transplanted into MHC …
induce tolerance of themselves and of cardiac allografts across a full-MHC barrier in
miniature swine. However, the renal element (s) responsible for kidney-induced cardiac
allograft tolerance (KICAT) are unknown. Here we investigated whether MHC disparities
between parenchyma versus hematopoietic-derived “passenger” cells of the heart and
kidney allografts affected KICAT. Heart and kidney allografts were co-transplanted into MHC …