An improved technique of thymectomy in the adult mouse
RP DeMatteo, JF Markmann, SE Raper - Transplantation, 1995 - journals.lww.com
RP DeMatteo, JF Markmann, SE Raper
Transplantation, 1995•journals.lww.comThe thymus plays an essential role in T cell ontogeny.(I) Thymectomy has proven to be an
invaluable tool in rodents for studying the function of T lymphocytes in autoimmunity,
infection, tumor immunity, tolerance, and transplantation (2). The technique of thymectomy in
the mouse is well described and remains largely unchanged from its original description (3).
The procedure, however, is commonly associated with significant mortality that is usually not
reported. Operative mortality is highly variable and depends on the
invaluable tool in rodents for studying the function of T lymphocytes in autoimmunity,
infection, tumor immunity, tolerance, and transplantation (2). The technique of thymectomy in
the mouse is well described and remains largely unchanged from its original description (3).
The procedure, however, is commonly associated with significant mortality that is usually not
reported. Operative mortality is highly variable and depends on the
The thymus plays an essential role in T cell ontogeny.(I) Thymectomy has proven to be an invaluable tool in rodents for studying the function of T lymphocytes in autoimmunity, infection, tumor immunity, tolerance, and transplantation (2). The technique of thymectomy in the mouse is well described and remains largely unchanged from its original description (3). The procedure, however, is commonly associated with significant mortality that is usually not reported. Operative mortality is highly variable and depends on the
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