[HTML][HTML] Depletion of Foxp3+ T cells abrogates tolerance of skin and heart allografts in murine mixed chimeras without the loss of mixed chimerism
K Shinoda, T Akiyoshi, CM Chase, EA Farkash… - American Journal of …, 2014 - Elsevier
The relative contribution of central and peripheral mechanisms to the generation and
maintenance of allograft tolerance is of considerable interest. Here, we present new
evidence that regulatory T cells (Foxp3+) maintain skin and heart allograft tolerance in
mixed hematopoietic chimeric mice. Transient depletion of both donor-and recipient-derived
Foxp3+ cells was necessary and sufficient to induce decisive rejection of long-accepted skin
and heart allografts. In contrast, stable hematopoietic chimerism remained, and there was no …
maintenance of allograft tolerance is of considerable interest. Here, we present new
evidence that regulatory T cells (Foxp3+) maintain skin and heart allograft tolerance in
mixed hematopoietic chimeric mice. Transient depletion of both donor-and recipient-derived
Foxp3+ cells was necessary and sufficient to induce decisive rejection of long-accepted skin
and heart allografts. In contrast, stable hematopoietic chimerism remained, and there was no …