Role of complement and NK cells in antibody mediated rejection
T Akiyoshi, T Hirohashi, A Alessandrini, CM Chase… - Human immunology, 2012 - Elsevier
Despite extensive research on T cells and potent immunosuppressive regimens that target
cellular mediated rejection, few regimens have been proved to be effective on antibody-
mediated rejection (AMR), particularly in the chronic setting. C4d deposition in the graft has
been proved to be a useful marker for AMR; however, there is an imperfect association
between C4d and AMR. While complement has been considered as the main player in
acute AMR, the effector mechanisms in chronic AMR are still debated. Recent studies …
cellular mediated rejection, few regimens have been proved to be effective on antibody-
mediated rejection (AMR), particularly in the chronic setting. C4d deposition in the graft has
been proved to be a useful marker for AMR; however, there is an imperfect association
between C4d and AMR. While complement has been considered as the main player in
acute AMR, the effector mechanisms in chronic AMR are still debated. Recent studies …