Pattern of SIVagm infection in patas monkeys suggests that host adaptation to simian immunodeficiency virus infection may result in resistance to infection and virus …
C Apetrei, T Gaufin, R Gautam, C Vinton… - The Journal of …, 2010 - academic.oup.com
Patas monkeys were not reported to carry species-specific simian immunodeficiency virus
(SIV), but crossspecies transmission of SIVagm to patas monkeys occurred in the wild. We
report that patas monkeys share immunophenotypic features with natural hosts of SIV; that
is, low levels of CD4+ T cells and low CCR5 expression on CD4+ T cells. In 1 patas monkey
with undetectable levels of CD4+ T cells, experimental exposure to SIVagm did not result in
infection. The other experimentally infected patas monkeys showed an infection pattern …
(SIV), but crossspecies transmission of SIVagm to patas monkeys occurred in the wild. We
report that patas monkeys share immunophenotypic features with natural hosts of SIV; that
is, low levels of CD4+ T cells and low CCR5 expression on CD4+ T cells. In 1 patas monkey
with undetectable levels of CD4+ T cells, experimental exposure to SIVagm did not result in
infection. The other experimentally infected patas monkeys showed an infection pattern …
[HTML][HTML] Pattern of SIVagm infection in patas monkeys suggests that host adaptation to SIV infection may result in resistance to infection and virus extinction
C Apetrei, T Gaufin, R Gautam, C Vinton… - The Journal of …, 2010 - ncbi.nlm.nih.gov
Patas were not reported to carry a species-specific SIV, but SIVagm cross-species
transmission to patas occurred in the wild. We report that patas share immunophenotypic
features with natural hosts of SIV, ie, low levels of CD4+ T cells and low CCR5 expression
on CD4+ T cells. In one patas with undetectable levels of CD4+ T cells, experimental
exposure to SIVagm did not result in infection. Remaining experimentally-infected patas
showed an infection pattern similar to SIV infection in natural hosts. Thus, downregulation of …
transmission to patas occurred in the wild. We report that patas share immunophenotypic
features with natural hosts of SIV, ie, low levels of CD4+ T cells and low CCR5 expression
on CD4+ T cells. In one patas with undetectable levels of CD4+ T cells, experimental
exposure to SIVagm did not result in infection. Remaining experimentally-infected patas
showed an infection pattern similar to SIV infection in natural hosts. Thus, downregulation of …