The clinically used photosensitizer Verteporfin (VP) inhibits YAP-TEAD and human retinoblastoma cell growth in vitro without light activation
K Brodowska, A Al-Moujahed, A Marmalidou… - Experimental eye …, 2014 - Elsevier
Verteporfin (VP), a benzoporphyrin derivative, is clinically used in photodynamic therapy for
neovascular macular degeneration. Recent studies indicate that VP may inhibit growth of
hepatoma cells without photoactivation through inhibition of YAP-TEAD complex. In this
study, we examined the effects of VP without light activation on human retinoblastoma cell
lines. Verteporfin but not vehicle control inhibited the growth, proliferation and viability of
human retinoblastoma cell lines (Y79 and WERI) in a dose-dependent manner and was …
neovascular macular degeneration. Recent studies indicate that VP may inhibit growth of
hepatoma cells without photoactivation through inhibition of YAP-TEAD complex. In this
study, we examined the effects of VP without light activation on human retinoblastoma cell
lines. Verteporfin but not vehicle control inhibited the growth, proliferation and viability of
human retinoblastoma cell lines (Y79 and WERI) in a dose-dependent manner and was …