Generation of VSV pseudotypes using recombinant ΔG-VSV for studies on virus entry, identification of entry inhibitors, and immune responses to vaccines

MA Whitt - Journal of virological methods, 2010 - Elsevier
Vesicular stomatitis virus (VSV) is a prototypic enveloped animal virus that has been used
extensively to study virus entry, replication and assembly due to its broad host range and
robust replication properties in a wide variety of mammalian and insect cells. Studies on
VSV assembly led to the creation of a recombinant VSV in which the glycoprotein (G) gene
was deleted. This recombinant (rVSV-ΔG) has been used to produce VSV pseudotypes
containing the envelope glycoproteins of heterologous viruses, including viruses that require …