Blockade of IL-6-signaling inhibits the pathogenesis of CD4+ T cell-mediated lethal graft-versus-host reaction against minor histocompatibility antigen
D Noguchi, D Wakita, T Ohkuri, M Tajima, K Chamoto… - Immunology …, 2011 - Elsevier
Graft-versus-host reaction (GVHR) is considered as a problem in hematopoietic cell
transplantation. We found that CD45RBhigh CD62L+ naïve CD4+ T cells from wild-type
B10D2 (H-2d MMTV6−) mice immediately differentiated into effector T cells producing high-
levels of various cytokines after the transfer into BALB/c RAG2−/−(H-2d MMTV6+) mice. The
expanded CD4+ T cells, which have almost TCR Vβ3 chain, recognized the minor antigen of
recipient mice and brought typical severe GVHR symptoms such as eyelid irritation …
transplantation. We found that CD45RBhigh CD62L+ naïve CD4+ T cells from wild-type
B10D2 (H-2d MMTV6−) mice immediately differentiated into effector T cells producing high-
levels of various cytokines after the transfer into BALB/c RAG2−/−(H-2d MMTV6+) mice. The
expanded CD4+ T cells, which have almost TCR Vβ3 chain, recognized the minor antigen of
recipient mice and brought typical severe GVHR symptoms such as eyelid irritation …
