[HTML][HTML] STAT3 regulates cytokine-mediated generation of inflammatory helper T cells

XO Yang, AD Panopoulos, R Nurieva… - Journal of Biological …, 2007 - ASBMB
Interleukin-17 (IL-17)-producing helper T (TH) cells, named as TH IL-17, TH17, or
inflammatory TH (THi), have been recently identified as a novel effector lineage. However,
how cytokine signals mediate THi differentiation is unclear. We found that IL-6 functioned to
up-regulate IL-23R and that IL-23 synergized with IL-6 in promoting THi generation. STAT3,
activated by both IL-6 and IL-23, plays a critical role in THi development. A hyperactive form
of STAT3 promoted THi development, whereas this differentiation process was greatly …