Divergence of helper, cytotoxic, and regulatory T cells in the decidua from miscarriage

Y Ebina, S Shimada, M Deguchi… - American Journal of …, 2016 - Wiley Online Library
Y Ebina, S Shimada, M Deguchi, Y Maesawa, N Iijima, H Yamada
American Journal of Reproductive Immunology, 2016Wiley Online Library
Problem The aim of this prospective study was to evaluate phenotypic differences of helper
T (Th), cytotoxic T (Tc), and regulatory T (Treg) cells in the deciduae of missed miscarriage
with a normal chromosome karyotype of a fetus (MN) and missed miscarriage with an
abnormal chromosome karyotype of a fetus (MA). Methods of study The decidua of 19 MN
and 28 MA was obtained. Additionally, the decidua of 15 induced abortion (IA) and the
endometrium of 19 non‐pregnant women (EM) were obtained. IFN‐γ+, IL‐17+, CD …
Problem
The aim of this prospective study was to evaluate phenotypic differences of helper T (Th), cytotoxic T (Tc), and regulatory T (Treg) cells in the deciduae of missed miscarriage with a normal chromosome karyotype of a fetus (MN) and missed miscarriage with an abnormal chromosome karyotype of a fetus (MA).
Methods of study
The decidua of 19 MN and 28 MA was obtained. Additionally, the decidua of 15 induced abortion (IA) and the endometrium of 19 non‐pregnant women (EM) were obtained. IFN‐γ+, IL‐17+, CD25highFoxp3+ cells in CD4+ (Th) cells, and IFN‐γ+ cells in CD8+ (Tc) cells were evaluated by flow cytometry.
Results
The percentages of IFN‐γ+ Tc and CD4+CD25highFoxp3+ (Treg) cells in MN were significantly increased as compared with MA and IA. The percentage of IFN‐γ+ Th in MN was increased as compared with IA.
Conclusion
Activation of IFN‐γ+ Tc and Treg cells in the decidua might be associated with the pathophysiology underlying MN.
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