Decidual macrophages are potentially susceptible to inhibition by class Ia and class Ib HLA molecules
MG Petroff, P Sedlmayr, D Azzola, JS Hunt - Journal of reproductive …, 2002 - Elsevier
Several members of the immunoglobulin-like transcript (ILT), also called leukocyte
immunoglobulin-like receptor (LIR), family of transmembrane proteins have been identified
as receptors for class I HLA molecules and transduce inhibitory signals to leukocytes upon
binding of these ligands. The ligands for ILT2 (LIR1/CD85j) and ILT4 (LIR2/CD85d) include
HLA-A,-B, and-G, the last of which is highly expressed in fetal trophoblast cells in both
membrane-bound and soluble isoforms. To investigate the potential of fetally-derived HLA …
immunoglobulin-like receptor (LIR), family of transmembrane proteins have been identified
as receptors for class I HLA molecules and transduce inhibitory signals to leukocytes upon
binding of these ligands. The ligands for ILT2 (LIR1/CD85j) and ILT4 (LIR2/CD85d) include
HLA-A,-B, and-G, the last of which is highly expressed in fetal trophoblast cells in both
membrane-bound and soluble isoforms. To investigate the potential of fetally-derived HLA …