[HTML][HTML] Phagocytosis mediated by scavenger receptor class BI promotes macrophage transition during skeletal muscle regeneration

J Zhang, C Qu, T Li, W Cui, X Wang, J Du - Journal of Biological Chemistry, 2019 - ASBMB
Macrophages play an essential role in skeletal muscle regeneration. The phagocytosis of
muscle cell debris induces a switch of pro-inflammatory macrophages into an anti-
inflammatory phenotype, but the cellular receptors mediating this phagocytosis are still
unclear. In this paper, we report novel roles for SRB1 (scavenger receptor class BI) in
regulating macrophage phagocytosis and macrophage phenotypic transitions for skeletal
muscle regeneration. In a mouse model of cardiotoxin-induced muscle injury/regeneration …