[HTML][HTML] Functional consequences of glucagon-like peptide-1 receptor cross-talk and trafficking
SN Roed, AC Nøhr, P Wismann, H Iversen… - Journal of Biological …, 2015 - ASBMB
The signaling capacity of seven-transmembrane/G-protein-coupled receptors (7TM/GPCRs)
can be regulated through ligand-mediated receptor trafficking. Classically, the recycling of
internalized receptors is associated with resensitization, whereas receptor degradation
terminates signaling. We have shown previously that the incretin glucagon-like peptide-1
receptor (GLP-1R) internalizes fast and is primarily resensitized through recycling back to
the cell surface. GLP-1R is expressed in pancreatic islets together with the closely related …
can be regulated through ligand-mediated receptor trafficking. Classically, the recycling of
internalized receptors is associated with resensitization, whereas receptor degradation
terminates signaling. We have shown previously that the incretin glucagon-like peptide-1
receptor (GLP-1R) internalizes fast and is primarily resensitized through recycling back to
the cell surface. GLP-1R is expressed in pancreatic islets together with the closely related …