Effect of noninsulin antidiabetic drugs added to metformin therapy on glycemic control, weight gain, and hypoglycemia in type 2 diabetes
OJ Phung, JM Scholle, M Talwar, CI Coleman - Jama, 2010 - jamanetwork.com
Context Metformin is the recommended initial drug therapy for patients with type 2 diabetes
mellitus (DM). However, the optimal second-line drug when metformin monotherapy fails is
unclear. Objective To determine the comparative efficacy, risk of weight gain, and
hypoyglycemia associated with noninsulin antidiabetic drugs in patients with type 2 DM not
controlled by metformin alone. Data Sources A literature search via MEDLINE (beginning in
January 1950) and Cochrane CENTRAL through January 2010 and a manual search of …
mellitus (DM). However, the optimal second-line drug when metformin monotherapy fails is
unclear. Objective To determine the comparative efficacy, risk of weight gain, and
hypoyglycemia associated with noninsulin antidiabetic drugs in patients with type 2 DM not
controlled by metformin alone. Data Sources A literature search via MEDLINE (beginning in
January 1950) and Cochrane CENTRAL through January 2010 and a manual search of …