An experimental model of secondary progressive multiple sclerosis that shows regional variation in gliosis, remyelination, axonal and neuronal loss
Multiple sclerosis (MS) represents a considerable challenge to experimentally model due to
its twin pathologies of inflammatory demyelination and neurodegeneration along with its
multifocal and multiphasic nature. Experimental autoimmune encephalomyelitis (EAE) in
Biozzi ABH mice has previously been shown to reproduce many clinical features also found
in secondary progressive MS. In this study we sought to characterise the pathology of
chronic EAE in ABH mice. In addition to marked gliosis, we report substantial demyelination …
its twin pathologies of inflammatory demyelination and neurodegeneration along with its
multifocal and multiphasic nature. Experimental autoimmune encephalomyelitis (EAE) in
Biozzi ABH mice has previously been shown to reproduce many clinical features also found
in secondary progressive MS. In this study we sought to characterise the pathology of
chronic EAE in ABH mice. In addition to marked gliosis, we report substantial demyelination …