Experimental allergic encephalomyelitis (EAE) was induced in Biozzi AB/H (antibody high)
mice by sensitization with spinal cord homogenate in adjuvant. Biozzi AB/H mice were
highly susceptible to EAE induction and followed a chronic relapsing pattern of disease.
Disease episodes were characterized by mononuclear infiltration of the central nervous
system, with demyelination being particularly evident in relapse. The cellular infiltrates,
which were associated with immunoglobulin deposition, consisted of macrophages and …