BACKGROUND: Volumetric changes and glial pathology have been reported in the central
nervous system (CNS) of patients with depressive disorder, an illness often associated with
elevated glucocorticoid levels. Glucocorticoids reduce gliogenesis in the adult rat CNS.
Electroconvulsive seizure (ECS)-treatment, an animal model for the antidepressant
treatment electroconvulsive therapy, can enhance proliferation of glial cells. This study
examined glial cell proliferation in response to ECS in rats whose glucocorticoid levels were …