Publisher Summary Functional characterization of a protein sequence is one of the most
frequent problems in biology. This task is usually facilitated by accurate three-dimensional
(3D) structure of the studied protein. In the absence of an experimentally determined
structure, comparative or homology modeling can sometimes provide a useful 3D model for
a protein (target) that is related to at least one known protein structure (template). A 3D
structure of proteins from the same family is more conserved than their primary sequences …