The epigenetic regulator SIRT6 protects the liver from alcohol-induced tissue injury by reducing oxidative stress in mice
HG Kim, M Huang, Y Xin, Y Zhang, X Zhang… - Journal of …, 2019 - Elsevier
Background & Aims As a nicotinamide adenine dinucleotide-dependent deacetylase and a
key epigenetic regulator, sirtuin 6 (SIRT6) has been implicated in the regulation of
metabolism, DNA repair, and inflammation. However, the role of SIRT6 in alcohol-related
liver disease (ALD) remains unclear. The aim of this study was to investigate the function
and mechanism of SIRT6 in ALD pathogenesis. Methods We developed and characterized
Sirt6 knockout (KO) and transgenic mouse models that were treated with either control or …
key epigenetic regulator, sirtuin 6 (SIRT6) has been implicated in the regulation of
metabolism, DNA repair, and inflammation. However, the role of SIRT6 in alcohol-related
liver disease (ALD) remains unclear. The aim of this study was to investigate the function
and mechanism of SIRT6 in ALD pathogenesis. Methods We developed and characterized
Sirt6 knockout (KO) and transgenic mouse models that were treated with either control or …