[HTML][HTML] The signaling protein Wnt5a promotes TGFβ1-mediated macrophage polarization and kidney fibrosis by inducing the transcriptional regulators Yap/Taz
Y Feng, Y Liang, X Zhu, M Wang, Y Gui, Q Lu… - Journal of Biological …, 2018 - ASBMB
M2 macrophage polarization is known to underlie kidney fibrosis. We previously reported
that most of the members of the Wnt family of signaling proteins are induced in fibrotic
kidneys. Dysregulation of the signaling protein Wnt5a is associated with fibrosis, but little is
known about the role of Wnt5a in regulating M2 macrophage activation that results in kidney
fibrosis. Here, using murine Raw 264.7 cells and bone marrow–derived macrophages, we
found that Wnt5a enhanced transforming growth factor β1 (TGFβ1)-induced macrophage M2 …
that most of the members of the Wnt family of signaling proteins are induced in fibrotic
kidneys. Dysregulation of the signaling protein Wnt5a is associated with fibrosis, but little is
known about the role of Wnt5a in regulating M2 macrophage activation that results in kidney
fibrosis. Here, using murine Raw 264.7 cells and bone marrow–derived macrophages, we
found that Wnt5a enhanced transforming growth factor β1 (TGFβ1)-induced macrophage M2 …