Vascular endothelial growth factor induces chemotaxis and proliferation of microglial cells
F Forstreuter, R Lucius, R Mentlein - Journal of neuroimmunology, 2002 - Elsevier
Vascular endothelial growth factor (VEGF) is an angiogenic peptide that is produced in the
brain after ischemia, injury or in malignant gliomas. Since these pathological conditions are
associated with the infiltration of microglial cells, we investigated the expression of VEGF
receptors (VEGFR) and possible effects of VEGF on cultivated microglial cells. As shown by
reverse transcription-polymerase chain reaction and immunocytochemistry, rat microglial
cells as well as the murine cell line BV-2 express the VEGFR-1, but not VEGFR-2. Murine …
brain after ischemia, injury or in malignant gliomas. Since these pathological conditions are
associated with the infiltration of microglial cells, we investigated the expression of VEGF
receptors (VEGFR) and possible effects of VEGF on cultivated microglial cells. As shown by
reverse transcription-polymerase chain reaction and immunocytochemistry, rat microglial
cells as well as the murine cell line BV-2 express the VEGFR-1, but not VEGFR-2. Murine …