Microglia-derived pronerve growth factor promotes photoreceptor cell death via p75 neurotrophin receptor
B Srinivasan, CH Roque, BL Hempstead… - Journal of Biological …, 2004 - jbc.org
Reports implicating microglia-derived nerve growth factor (NGF) during programmed cell
death in the developing chick retina led us to investigate its possible role in degenerative
retinal disease. Freshly isolated activated retinal microglia expressed high molecular weight
forms of neurotrophins including that of nerve growth factor (NGF), brain-derived
neurotrophic factor, neurotrophin-3, and neurotrophin-4. Conditioned media from cultured
retinal microglia (MGCM) consistently yielded a∼ 32-kDa NGF-reactive band when …
death in the developing chick retina led us to investigate its possible role in degenerative
retinal disease. Freshly isolated activated retinal microglia expressed high molecular weight
forms of neurotrophins including that of nerve growth factor (NGF), brain-derived
neurotrophic factor, neurotrophin-3, and neurotrophin-4. Conditioned media from cultured
retinal microglia (MGCM) consistently yielded a∼ 32-kDa NGF-reactive band when …
