Transcription factors of the NFAT family: regulation and function
A Rao, C Luo, PG Hogan - Annual review of immunology, 1997 - annualreviews.org
▪ Abstract As targets for the immunosuppressive drugs cyclosporin A and FK506,
transcription factors of the NFAT (nuclear factor of activated T cells) family have been the
focus of much attention. NFAT proteins, which are expressed in most immune-system cells,
play a pivotal role in the transcription of cytokine genes and other genes critical for the
immune response. The activity of NFAT proteins is tightly regulated by the
calcium/calmodulin-dependent phosphatase calcineurin, a primary target for inhibition by …
transcription factors of the NFAT (nuclear factor of activated T cells) family have been the
focus of much attention. NFAT proteins, which are expressed in most immune-system cells,
play a pivotal role in the transcription of cytokine genes and other genes critical for the
immune response. The activity of NFAT proteins is tightly regulated by the
calcium/calmodulin-dependent phosphatase calcineurin, a primary target for inhibition by …
