Heterogeneity of chronic lung allograft dysfunction: insights from protein expression in broncho alveolar lavage
SE Verleden, R Vos, V Mertens… - The Journal of heart and …, 2011 - Elsevier
BACKGROUND: Chronic lung allograft dysfunction (CLAD) remains a major risk factor for
death after lung transplantation. Previous data suggested that within CLAD at least 2
phenotypes are present: a neutrophilic type (nCLAD or neutrophilic reversible allograft
dysfunction [NRAD]), reversible with azithromycin therapy, vs a low neutrophilic type, non-
responsive to azithromycin (fibrotic bronchiolitis obliterans syndrome [fBOS]). We aimed to
further characterize this dichotomy by measuring multiple proteins in the bronchoalveolar …
death after lung transplantation. Previous data suggested that within CLAD at least 2
phenotypes are present: a neutrophilic type (nCLAD or neutrophilic reversible allograft
dysfunction [NRAD]), reversible with azithromycin therapy, vs a low neutrophilic type, non-
responsive to azithromycin (fibrotic bronchiolitis obliterans syndrome [fBOS]). We aimed to
further characterize this dichotomy by measuring multiple proteins in the bronchoalveolar …
