[HTML][HTML] Donor pretreatment with nebulized complement C3a receptor antagonist mitigates brain-death induced immunological injury post–lung transplant
Q Cheng, K Patel, B Lei, L Rucker, DP Allen… - American Journal of …, 2018 - Elsevier
Donor brain death (BD) is an inherent part of lung transplantation (LTx) and a key contributor
to ischemia-reperfusion injury (IRI). Complement activation occurs as a consequence of BD
in other solid organ Tx and exacerbates IRI, but the role of complement in LTx has not been
investigated. Here, we investigate the utility of delivering nebulized C3a receptor antagonist
(C3aRA) pretransplant to BD donor lungs in order to reduce post-LTx IRI. BD was induced in
Balb/c donors, and lungs nebulized with C3aRA or vehicle 30 minutes prior to lung …
to ischemia-reperfusion injury (IRI). Complement activation occurs as a consequence of BD
in other solid organ Tx and exacerbates IRI, but the role of complement in LTx has not been
investigated. Here, we investigate the utility of delivering nebulized C3a receptor antagonist
(C3aRA) pretransplant to BD donor lungs in order to reduce post-LTx IRI. BD was induced in
Balb/c donors, and lungs nebulized with C3aRA or vehicle 30 minutes prior to lung …
