Safety, immunogenicity and efficacy of a pre-erythrocytic malaria candidate vaccine, ICC-1132 formulated in Seppic ISA 720

M Walther, S Dunachie, S Keating, T Berthoud… - Vaccine, 2005 - Elsevier
M Walther, S Dunachie, S Keating, T Berthoud, A Schmidt, C Maier, L Andrews…
Vaccine, 2005Elsevier
ICC-1132, a recombinant virus-like particle comprising of a modified hepatitis B core protein
with a B cell (NANP) and two T cell epitopes of Plasmodium falciparum circumsporozoite
protein (CSP), was administered im as a single 50μg dose in Seppic ISA 720 to 11
volunteers. Local reactogenicity and systemic side effects were acceptable with the
predominant finding being mild pain at the injection site. This regimen induced anti-NANP
antibodies in 10/11 and modest T cell responses. There was no evidence of protection from …
ICC-1132, a recombinant virus-like particle comprising of a modified hepatitis B core protein with a B cell (NANP) and two T cell epitopes of Plasmodium falciparum circumsporozoite protein (CSP), was administered i.m. as a single 50μg dose in Seppic ISA 720 to 11 volunteers. Local reactogenicity and systemic side effects were acceptable with the predominant finding being mild pain at the injection site. This regimen induced anti-NANP antibodies in 10/11 and modest T cell responses. There was no evidence of protection from experimental challenge with P. falciparum sporozoites. Other formulations and/or multi-dose regimens will be required to enhance the immunogenicity and efficacy of ICC-1132.
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