[HTML][HTML] Infectivity-associated changes in the transcriptional repertoire of the malaria parasite sporozoite stage
K Matuschewski, J Ross, SM Brown, K Kaiser… - Journal of Biological …, 2002 - ASBMB
Injection of Plasmodium salivary gland sporozoites into the vertebrate host byAnopheles
mosquitoes initiates malaria infection. Sporozoites develop within oocysts in the mosquito
midgut and then enter and mature in the salivary glands. Although morphologically similar,
oocyst sporozoites and salivary gland sporozoites differ strikingly in their infectivity to the
mammalian host, ability to elicit protective immune responses, and cell motility. Here, we
show that differential gene expression coincides with these dramatic phenotypic differences …
mosquitoes initiates malaria infection. Sporozoites develop within oocysts in the mosquito
midgut and then enter and mature in the salivary glands. Although morphologically similar,
oocyst sporozoites and salivary gland sporozoites differ strikingly in their infectivity to the
mammalian host, ability to elicit protective immune responses, and cell motility. Here, we
show that differential gene expression coincides with these dramatic phenotypic differences …