Cutting edge: CD8 T cells specific for lymphocytic choriomeningitis virus require type I IFN receptor for clonal expansion

P Aichele, H Unsoeld, M Koschella… - The Journal of …, 2006 - journals.aai.org
P Aichele, H Unsoeld, M Koschella, O Schweier, U Kalinke, S Vucikuja
The Journal of Immunology, 2006journals.aai.org
The role of type I IFN signaling in CD8 T cells was analyzed in an adoptive transfer model
using P14 TCR transgenic CD8 T cells specific for lymphocytic choriomeningitis virus
(LCMV) but deficient in type I IFNR. In the present study, we demonstrate severe impairment
in the capacity of P14 T cells lacking type I IFNR to expand in normal type I IFNR wild-type
C57BL/6 hosts after LCMV infection. In contrast, following infection of recipient mice with
recombinant vaccinia virus expressing LCMV glycoprotein, P14 T cell expansion was …
Abstract
The role of type I IFN signaling in CD8 T cells was analyzed in an adoptive transfer model using P14 TCR transgenic CD8 T cells specific for lymphocytic choriomeningitis virus (LCMV) but deficient in type I IFNR. In the present study, we demonstrate severe impairment in the capacity of P14 T cells lacking type I IFNR to expand in normal type I IFNR wild-type C57BL/6 hosts after LCMV infection. In contrast, following infection of recipient mice with recombinant vaccinia virus expressing LCMV glycoprotein, P14 T cell expansion was considerably less dependent on type I IFNR expression. Lack of type I IFNR expression by P14 T cells did not affect cell division after LCMV infection but interfered with clonal expansion. Thus, direct type I IFN signaling is essential for CD8 T cell survival in certain viral infections.
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