Peroxisome proliferator-activated receptor δ activators induce IL-8 expression in nonstimulated endothelial cells in a transcriptional and posttranscriptional manner
M Meissner, I Hrgovic, M Doll, J Naidenow… - Journal of biological …, 2010 - jbc.org
Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription
factors that are implicated in the regulation of lipid and glucose homeostasis. PPAR agonists
have been shown to control inflammatory processes, in part by inhibiting distinct
proinflammatory genes (eg Il-1β and IFN-γ). IL-8 is a member of the proinflammatory
chemokine family that is important for various functions, such as mediating the adhesion of
eosinophilic granulocytes onto endothelial cells. The influence of PPARδ activators on the …
factors that are implicated in the regulation of lipid and glucose homeostasis. PPAR agonists
have been shown to control inflammatory processes, in part by inhibiting distinct
proinflammatory genes (eg Il-1β and IFN-γ). IL-8 is a member of the proinflammatory
chemokine family that is important for various functions, such as mediating the adhesion of
eosinophilic granulocytes onto endothelial cells. The influence of PPARδ activators on the …
