[HTML][HTML] Regulation of transforming growth factor-β-dependent cyclooxygenase-2 expression in fibroblasts

T Matsumura, T Suzuki, K Aizawa, D Sawaki… - Journal of biological …, 2009 - ASBMB
Abnormal transforming growth factor-β (TGF-β) signaling is a critical contributor to the
pathogenesis of various human diseases ranging from tissue fibrosis to tumor formation.
Excessive TGF-β signaling stimulates fibrotic responses. Recent research has focused in the
main on the antiproliferative effects of TGF-β in fibroblasts, and it is presently understood that
TGF-β-stimulated cyclooxygenase-2 (COX-2) induction in fibroblasts is essential for
antifibroproliferative effects of TGF-β. Both TGF-β and COX-2 have been implicated in tumor …