[HTML][HTML] The C-terminal fibrinogen-like domain of angiopoietin-like 4 stimulates adipose tissue lipolysis and promotes energy expenditure
AE McQueen, D Kanamaluru, K Yan, NE Gray… - Journal of Biological …, 2017 - ASBMB
Angptl4 (Angiopoietin-like 4) is a circulating protein secreted by white and brown adipose
tissues and the liver. Structurally, Angptl4 contains an N-terminal coiled-coil domain (CCD)
connected to a C-terminal fibrinogen-like domain (FLD) via a cleavable linker, and both full-
length Angptl4 and its individual domains circulate in the bloodstream. Angptl4 inhibits
extracellular lipoprotein lipase (LPL) activity and stimulates the lipolysis of triacylglycerol
stored by adipocytes in the white adipose tissue (WAT). The former activity is furnished by …
tissues and the liver. Structurally, Angptl4 contains an N-terminal coiled-coil domain (CCD)
connected to a C-terminal fibrinogen-like domain (FLD) via a cleavable linker, and both full-
length Angptl4 and its individual domains circulate in the bloodstream. Angptl4 inhibits
extracellular lipoprotein lipase (LPL) activity and stimulates the lipolysis of triacylglycerol
stored by adipocytes in the white adipose tissue (WAT). The former activity is furnished by …