[HTML][HTML] Angiopoietin-like 4 promotes the intracellular cleavage of lipoprotein lipase by PCSK3/furin in adipocytes
W Dijk, PMM Ruppert, LJ Oost, S Kersten - Journal of Biological Chemistry, 2018 - ASBMB
Lipoprotein lipase (LPL) catalyzes the breakdown of circulating triglycerides in muscle and
fat. LPL is inhibited by several proteins, including angiopoietin-like 4 (ANGPTL4), and may
be cleaved by members of the proprotein convertase subtilisin/kexin (PCSK) family. Here,
we aimed to investigate the cleavage of LPL in adipocytes by PCSKs and study the potential
involvement of ANGPTL4. A substantial portion of LPL in mouse and human adipose tissue
was cleaved into N-and C-terminal fragments. Treatment of different adipocytes with the …
fat. LPL is inhibited by several proteins, including angiopoietin-like 4 (ANGPTL4), and may
be cleaved by members of the proprotein convertase subtilisin/kexin (PCSK) family. Here,
we aimed to investigate the cleavage of LPL in adipocytes by PCSKs and study the potential
involvement of ANGPTL4. A substantial portion of LPL in mouse and human adipose tissue
was cleaved into N-and C-terminal fragments. Treatment of different adipocytes with the …