[HTML][HTML] ANGPTL8 requires ANGPTL3 to inhibit lipoprotein lipase and plasma triglyceride clearance [S]
JF Haller, IJ Mintah, LM Shihanian, P Stevis… - Journal of lipid …, 2017 - ASBMB
Abstract Angiopoietin-like (ANGPTL) 3 and ANGPTL8 are secreted proteins and inhibitors of
LPL-mediated plasma triglyceride (TG) clearance. It is unclear how these two ANGPTL
proteins interact to regulate LPL activity. ANGPTL3 inhibits LPL activity and increases serum
TG independent of ANGPTL8. These effects are reversed with an ANGPTL3 blocking
antibody. Here, we show that ANGPTL8, although it possesses a functional inhibitory motif,
is inactive by itself and requires ANGPTL3 expression to inhibit LPL and increase plasma …
LPL-mediated plasma triglyceride (TG) clearance. It is unclear how these two ANGPTL
proteins interact to regulate LPL activity. ANGPTL3 inhibits LPL activity and increases serum
TG independent of ANGPTL8. These effects are reversed with an ANGPTL3 blocking
antibody. Here, we show that ANGPTL8, although it possesses a functional inhibitory motif,
is inactive by itself and requires ANGPTL3 expression to inhibit LPL and increase plasma …