Fasting is associated with significant changes in nutrient metabolism, many of which are
governed by transcription factors that regulate the expression of rate-limiting enzymes. One
factor that plays an important role in the metabolic response to fasting is the peroxisome
proliferator-activated receptor α (PPARα). To gain more insight into the role of PPARα during
fasting, and into the regulation of metabolism during fasting in general, a search for
unknown PPARα target genes was performed. Using subtractive hybridization (SABRE) …