[HTML][HTML] Identification of a new functional domain in angiopoietin-like 3 (ANGPTL3) and angiopoietin-like 4 (ANGPTL4) involved in binding and inhibition of lipoprotein …
EC Lee, U Desai, G Gololobov, S Hong, X Feng… - Journal of Biological …, 2009 - ASBMB
Angiopoietin-like 3 (ANGPTL3) and angiopoietin-like 4 (ANGPTL4) are secreted proteins
that regulate triglyceride (TG) metabolism in part by inhibiting lipoprotein lipase (LPL).
Recently, we showed that treatment of wild-type mice with monoclonal antibody (mAb)
14D12, specific for ANGPTL4, recapitulated the Angptl4 knock-out (-/-) mouse phenotype of
reduced serum TG levels. In the present study, we mapped the region of mouse ANGPTL4
recognized by mAb 14D12 to amino acids Gln 29–His 53, which we designate as specific …
that regulate triglyceride (TG) metabolism in part by inhibiting lipoprotein lipase (LPL).
Recently, we showed that treatment of wild-type mice with monoclonal antibody (mAb)
14D12, specific for ANGPTL4, recapitulated the Angptl4 knock-out (-/-) mouse phenotype of
reduced serum TG levels. In the present study, we mapped the region of mouse ANGPTL4
recognized by mAb 14D12 to amino acids Gln 29–His 53, which we designate as specific …