[HTML][HTML] Novel insight into KLF4 proteolytic regulation in estrogen receptor signaling and breast carcinogenesis
D Hu, Z Zhou, NE Davidson, Y Huang, Y Wan - Journal of Biological …, 2012 - ASBMB
Krüppel-like factor 4 (KLF4), a zinc finger-containing transcriptional factor, is a pivotal
regulator of cellular fate. KLF4 has attracted considerable attention for its opposing effect in
carcinogenesis as tumor suppressor (eg colorectal cancer) or oncoprotein (eg breast
cancer), depending on tissue context, with the underlying mechanism remaining largely
unknown. Here we report that KLF4 mediates estrogen signaling in breast cancer formation.
Accumulation of KLF4 by inhibiting its turnover triggers estrogen-induced transactivation. We …
regulator of cellular fate. KLF4 has attracted considerable attention for its opposing effect in
carcinogenesis as tumor suppressor (eg colorectal cancer) or oncoprotein (eg breast
cancer), depending on tissue context, with the underlying mechanism remaining largely
unknown. Here we report that KLF4 mediates estrogen signaling in breast cancer formation.
Accumulation of KLF4 by inhibiting its turnover triggers estrogen-induced transactivation. We …